Chemical engineers have always played an important role in the development of biotechnology. From the first efforts to effectively produce penicillin on a large scale to the newest advances in drug delivery, chemical engineers have been working hand in hand with biologists. In his lecture,...
This article offers guidance on how to design appropriate experiments to measure scalable data for agitation in both aerobic and anaerobic bioreactors.
Nitya M. Jacob, Wei-Shou Hu, Bernard Liat Wen Loo, and Miranda Yap , Wei shou Hu
Recombinant DNA technology transforms mammalian cells into factories for protein-based therapeutics. New techniques provide chemical engineers with a better understanding of the process as well as the cells themselves.
The use of complex living organisms, process variation, and lack of real-time measurements of key parameters are some of the challenges involved in automating a bioprocess. This article explains an indirect approach to monitoring and controlling a...
The production of stem-cell-based therapeutic products in large quantities is more complex than manufacturing molecular drugs. Scale-up and scale-out challenges arise related to the type of stem cell, cell expansion and banking, sterile handling,...
These experimental and modeling techniques enable the rapid, cost-effective design and scale-up of biopharmaceutical manufacturing in an integrated fashion.
A few basic types of bioreactor designs are used to produce a wide range of products, from antibiotics to foods to fuels. Here's how to pick the best options for your application.
Alex Patist, Aristos Aristidou , J. J. Hahn , Pim van Hoek
Designing an economically competitive and environmentally sustainable fermentation route means considering the downstream separations needed to capture the final product during the initial process design.
Disposable filtration systems are gaiing popularity in the pharmaceutical arena. This article defines the equipment, specifications, applications and potential advantages of single-use filters and ancillary equipment.