Bioprocessing

Hydrothermal Carbonization: Reactions and Water Production

Conference Presentation
AIChE Annual Meeting
Thursday, November 7, 2013 - 9:45am-10:15am
Hydrothermal carbonization (HTC) is a promising thermochemical conversion process for lignocellulosic biomass to offer value-added products. Biomass...

Effect of Anti-Apoptosis Genes On Clarification Performance

Conference Presentation
AIChE Annual Meeting
Wednesday, November 6, 2013 - 3:45pm-4:00pm
Optimal bioreactor harvest time is typically determined based on maximizing product titer without compromising product quality. We suggest that ease...

Syngas Mass Transfer Analysis in a Hollow Fiber Reactor

Conference Presentation
AIChE Annual Meeting
Monday, November 4, 2013 - 5:00pm-5:30pm
Biofuel production via fermentation is produced primarily by fermentation of simple sugars. Besides the sugar fermentation route , there exists a...

Upgrading of Biomass-Derived Liquid to Clean Fuels

Conference Presentation
AIChE Annual Meeting
Friday, November 2, 2012 - 9:00am-9:30am
The objective of this study is to develop and demonstrate a viable economical pathway to produce renewable transportation fuels from cellulosic biomass such as wood chips, forest wastes, and agriculture residues.

Cellulose Extraction From Rice Hulls Using Ionic Liquids

Conference Presentation
AIChE Annual Meeting
Tuesday, October 18, 2011 - 8:00pm
Over one fifth of calories consumed by humanity are from rice. Consequently, vast quantities of rice hulls are disposed of as waste, since the hull...

Cell Therapy Bioprocessing

Archived Webinar
Feb 8, 2011
As cellular therapies are advancing through clinical development and getting closer to market, close collaborations between stem cell biologists,...

Advances in Bioprocessing

Conference Presentation
AIChE Spring Meeting and Global Congress on Process Safety
Wednesday, April 29, 2009 - 4:30am
Please Note : Advances in Bioprocessing -- Spring Meeting 2009 includes the following recorded presentations: · Biofuel and Biochemical Productions...

Success and Prospects in Bioengineering

Conference Presentation
AIChE Annual Meeting
Sunday, November 16, 2008 - 7:00pm
Chemical engineers have always played an important role in the development of biotechnology. From the first efforts to effectively produce penicillin...

Rotating Algal Biofilm Reactor [On Location]

A new approach to address the problems of the large land area required for cultivation, culture contamination and the difficult and costly dewatering of the harvested cells in...
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Algal Biofuels: The Process

March
2011
SBE Special Section
Al Darzins, Eric P. Knoshaug
The production of algal biofuels involves algae cultivation, biomass harvesting and dewatering, lipid extraction, and conversion to fuel.

Piloting Bioreactors for Agitation Scale-Up

February
2008
Reactions and Separations
Gregory T. Benz
This article offers guidance on how to design appropriate experiments to measure scalable data for agitation in both aerobic and anaerobic bioreactors.

Using Genomic Tools to Improve the Production of Biologics

November
2009
SBE Special Section
Wei-Shou Hu, Nitya M. Jacob, Wei-Shou Hu, Bernard Liat Wen Loo, and Miranda Yap
Recombinant DNA technology transforms mammalian cells into factories for protein-based therapeutics. New techniques provide chemical engineers with a better understanding of the process as well as the cells themselves.

Fermentation Goes Large-Scale

January
2003
Special Section
Alex Patist, J. J. Hahn , Aristos Aristidou , Pim van Hoek
Designing an economically competitive and environmentally sustainable fermentation route means considering the downstream separations needed to capture the final product during the initial process design.

Integrating Single-Use Filtration Systems

January
2003
Special Section
Holly Haughney
Disposable filtration systems are gaiing popularity in the pharmaceutical arena. This article defines the equipment, specifications, applications and potential advantages of single-use filters and ancillary equipment.

Bioreactor Design for Chemical Engineers

August
2011
Back To Basics
Gregory T. Benz
Fermentation processes are based on chemical engineering principles. Understand these concepts to achieve optimal bioreactor design.

Consider Using Fluoropolymers in Biological Applications

December
2004
Materials
Victor Lusvardi , Sharon Libert, Lauri Jenkins
Even with the use of costly corrosion-resistant alloys, metal contamination continues to occur in the biologics industry, thus reducing product yield and activity. Fluoropolymers are emerging as a viable solution to this problem.

Avoid the Pitfalls of Bioprocess Development

August
2006
Process Development
Mukesh Doble
This article presents the challenges that an engineer might encounter when designing or scaling up bioprocesses and offers practical solutions, including those cited in literature.

Principles of Bioprocess Control

November
2009
SBE Special Section
Joseph S. Alford
The use of complex living organisms, process variation, and lack of real-time measurements of key parameters are some of the challenges involved in automating a bioprocess. This article explains an indirect approach to monitoring and controlling a...

Speeding the Design of Bioprocesses

May
2008
SBE Special Section
Sunil Chhatre , Andrew D. Tustian
These experimental and modeling techniques enable the rapid, cost-effective design and scale-up of biopharmaceutical manufacturing in an integrated fashion.

Minimize Scale-Up Risk

March
2010
SBE Special Section
Bertil Stromberg, Thomas Pschorn, J. Brad Cort
Proven commercial-scale equipment already exists for many operations involved in producing biofuels from lignocellulosic feedstocks.

Mother Nature as both Doctor and Patient

November
2006
SBE Special Section
Edwin N. Lightfoot
Once we have grasped some essentials of this riotous, but surprisingly well ordered world, we shall find our transport phenomena background to have real utility.

Keys to Bioreactor Selection

March
2002
Reactions and Separations
John A. Williams
A few basic types of bioreactor designs are used to produce a wide range of products, from antibiotics to foods to fuels. Here's how to pick the best options for your application.

Scaling Up Research to Commercial Manufacturing

November
2010
SBE Special Section
Erika Lapinskas
The production of stem-cell-based therapeutic products in large quantities is more complex than manufacturing molecular drugs. Scale-up and scale-out challenges arise related to the type of stem cell, cell expansion and banking, sterile handling,...

Bioprocess Design for a Novel Vaccine

November
2006
SBE Special Section
Barry C. Buckland
The challenges of vaccine development are not limited to identification of suitable antigens, adjuvants and delivery methods, but include regulatory, technical and manufacturing hurdles in translating a vaccine candidate to the clinic.
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