Biomedical Engineering

Tumor Targeting Theory: Physiological Limits from Scaling Analyses, and Design Principles for Better Magic Bullets

SBE Webinar

Sep 26, 2011

K Dane Wittrup

For the past two decades the capability of protein engineers to devise clever tumor-targeting molecules has outstripped our understanding of how these agents distribute through the body and permeate through tumors.

Microengineered Hydrogels for Stem Cell Bioengineering and Tissue Regeneration

SBE Webinar

Aug 23, 2011

Ali Khademhosseini

Micro- and nanoscale technologies are emerging as powerful tools for controlling the interaction between cells and their surroundings for biological studies, tissue eng

Engineering and Health Care

SBE Webinar

May 16, 2011

Robert Langer

Dr. Langer discusses the involvement of engineering in health care, from the discovery of the first angiogenesis inhibitors to the development of controlled drug delivery systems and the foundation of tissue engineering.

Short and Long-Term Changes in Circulatory Protein and Cytokine Profiles Following Burn and CLP Treatments

Nov 10, 2010

Mehmet A. Orman

Burns and trauma lead to a hypermetabolic state characterized by an accelerated breakdown of skeletal muscle protein in the patient which leads to muscle wasting and reduction of lean body Since burn patients in general experience a breakdown in gut barrier function that causes bacterial...

In Silico Modeling of the Immune Response Network: Influenza Immune-Escape Strategies and Implications in Influenza Drug Research

Nov 9, 2010

Jason E. Shoemaker

Recent evidence suggests that an overly ambitious immune response may be the primary factor that determines influenza severity [1], yet the definition of what is a reasonable immune response remains vague. Seasonal influenza, alone, is responsible for approximately 30,000 deaths in the US each year...

Genomic Approaches to Evolutionary History of Primate Cytochromes c

Nov 8, 2010

Lawrence I. Grossman

Cytochrome c (cyt c) is a highly conserved protein among eukaryotes, mainly owing to its pivotal role in two crucial cellular processes: apoptosis and respiratory chain function. Despite its overall stability, previous studies have reported on the human lineage: (i) a high amino acid evolution rate...

A System Approach to Astrocytoma Progression

Nov 8, 2010

Chunjing Wang

Astrocytomas are brain cancers that account for 75% of neuroepithelial tumors. Accurate diagnosis is required for adequate treatment and assessing prognosis for patients. We used both gene-based and network-based approaches to find the key processes involved in astrocytoma progression from...

Comprehensive Analysis of Liver Transcriptome Reveals Distinct Disease Signatures

Nov 8, 2010

Yuliang Wang

Major liver diseases such as hepatocellular carcinoma, cirrhosis, and hepatitis affect huge numbers of people. For example, each year, death from liver cancer alone is 662,000 worldwide. Early diagnosis of liver disease is crucial. If identified in time, hepatitis C patients can be treated with...

Gene Expression Profiling of Short- and Long-Term Changes in Rat Liver Following Burn Injury and CLP Treatment

Nov 8, 2010

Qian Yang

An important player in systemic hypermetabolism is the liver, which generally controls circulating levels of metabolites. It is well known that the hepatic response to severe injury and bacterial infections are characterized by a significant up-regulation of glucose, fatty acid, and amino acid...

Identification of Cell-Type Specific Transcripts for Informative Diagnostics

Nov 8, 2010

Younhee Ko

The identification of cell-type specific or brain-region specific transcripts adds specificity for the diagnosis of a wide variety of brain disorders, such as traumatic brain injury or brain cancers. One goal of identifying cell-type and brain-region specific genes is that they encode for proteins...

Multi-Scale Agent-Based Modeling of Human Endotoxemia

Nov 8, 2010

Tung T. Nguyen

The systemic inflammatory response syndrome (SIRS) often accompanies critical illness but is evoked by many stimuli e.g. infection, trauma, invasive surgery and biological stressors in general [1]. It often progresses to severe cases of sepsis with a substantial morbidity and mortality where...

Chronic Alcohol Effects On the System-Wide Transcriptional Regulatory Network Modules and Dynamics During Rat Liver Regeneration

Nov 8, 2010

Rajanikanth Vadigepalli

Liver regeneration is a complex, yet remarkably coordinated, process characterized by system-wide gene expression changes underlying the response of the liver tissue to acute damage through mechanical, chemical or viral mechanisms. This normal regenerative response is impaired by acute or chronic...

Body-on-a-Chip -- A Tool for Predictive Pharmacology/Toxicology

SBE Webinar

Mar 31, 2009

Michael L. Shuler

In this presentation, Professor Mike Shuler details his work to understand the response of the human body to various pharmaceutical and environmental chemicals using a combination of whole body modules and micro models Professor Shuler’s researc

Systems Biology: Open Challenges and Opportunities for Chemical Engineers

AIChE Webinar

Jan 20, 2009

Francis Doyle

Systems biology involves the analysis of multiple scales of 'control' in biological networks, from the regulation of gene transcription to the homeostatic regulation of metabolism in the whole body.

Engineering Organs: Heart and Esophagus

December

2007

SBE Special Section

Buddy D. Ratner

The potential for tissue engineering to transform the practice of medicine is enormous. Chemical engineers will play important roles in this revolution.

Developing Cell Therapy Biomanufacturing Processes

November

2010

SBE Special Section

Jon A. Rowley

Establishing scalable technology platforms that allow for varying levels of production throughout the different stages of clinical testing can minimize process development timelines, drug-comparability risks, and — ultimately — costs.

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Biomedical Engineering

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