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Biomedical Engineering

Chemical Engineers as Biomedical Innovators

AIChE Webinar
Aug 7, 2013
Sujata Bhatia
The design of biomedical materials is rooted in principles of chemical engineering. This presentation describes the connections between chemical engineering and biomedical innovations, and discusses the translation of novel materials into clinical applications.

Body-on-a-Chip -- A Tool for Predictive Pharmacology/Toxicology

SBE Webinar
Mar 31, 2009
Michael L. Shuler
In this presentation, Professor Mike Shuler details his work to understand the response of the human body to various pharmaceutical and environmental chemicals using a combination of whole body modules and micro models Professor Shuler’s researc

Bio-Based Materials Step into the Operating Room

September
2012
On The Horizon
Sujata K. Bhatia, M.D., P.E.
A new class of implantable medical materials — constructed from naturally derived and renewably sourced polymers — is poised to transform clinical medicine.

Engineering and Health Care

SBE Webinar
May 16, 2011
Robert Langer

Dr. Langer discusses the involvement of engineering in health care, from the discovery of the first angiogenesis inhibitors to the development of controlled drug delivery systems and the foundation of tissue engineering.

Developing Cell Therapy Biomanufacturing Processes

November
2010
SBE Special Section
Jon A. Rowley
Establishing scalable technology platforms that allow for varying levels of production throughout the different stages of clinical testing can minimize process development timelines, drug-comparability risks, and — ultimately — costs.

Identification of Cell-Type Specific Transcripts for Informative Diagnostics

Nov 8, 2010
Younhee Ko
The identification of cell-type specific or brain-region specific transcripts adds specificity for the diagnosis of a wide variety of brain disorders, such as traumatic brain injury or brain cancers. One goal of identifying cell-type and brain-region specific genes is that they encode for proteins...

Multi-Scale Agent-Based Modeling of Human Endotoxemia

Nov 8, 2010
Tung T. Nguyen
The systemic inflammatory response syndrome (SIRS) often accompanies critical illness but is evoked by many stimuli e.g. infection, trauma, invasive surgery and biological stressors in general [1]. It often progresses to severe cases of sepsis with a substantial morbidity and mortality where...

Genomic Approaches to Evolutionary History of Primate Cytochromes c

Nov 8, 2010
Lawrence I. Grossman
Cytochrome c (cyt c) is a highly conserved protein among eukaryotes, mainly owing to its pivotal role in two crucial cellular processes: apoptosis and respiratory chain function. Despite its overall stability, previous studies have reported on the human lineage: (i) a high amino acid evolution rate...

A System Approach to Astrocytoma Progression

Nov 8, 2010
Chunjing Wang
Astrocytomas are brain cancers that account for 75% of neuroepithelial tumors. Accurate diagnosis is required for adequate treatment and assessing prognosis for patients. We used both gene-based and network-based approaches to find the key processes involved in astrocytoma progression from...

Comprehensive Analysis of Liver Transcriptome Reveals Distinct Disease Signatures

Nov 8, 2010
Yuliang Wang
Major liver diseases such as hepatocellular carcinoma, cirrhosis, and hepatitis affect huge numbers of people. For example, each year, death from liver cancer alone is 662,000 worldwide. Early diagnosis of liver disease is crucial. If identified in time, hepatitis C patients can be treated with...

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