Using Genomic Tools to Improve the Production of Biologics

November
2009
SBE Special Section
Nitya M. Jacob, Wei-Shou Hu, Bernard Liat Wen Loo, and Miranda Yap , Wei-Shou Hu
Recombinant DNA technology transforms mammalian cells into factories for protein-based therapeutics. New techniques provide chemical engineers with a better understanding of the process as well as the cells themselves.

Your Personal Genome for $1,000?

November
2009
SBE Special Section
IBM scientists from four fields — nanofabrication, microelectronics, physics and biology — are collaborating to develop a “DNA transistor” that could make obtaining a personalized genome analysis easier, faster, and cheaper — ultimately as low as $...

Principles of Bioprocess Control

November
2009
SBE Special Section
Joseph S. Alford
The use of complex living organisms, process variation, and lack of real-time measurements of key parameters are some of the challenges involved in automating a bioprocess. This article explains an indirect approach to monitoring and controlling a...

SBE Update

July
2009
SBE Special Section
June Wispelwey
Improving Biopharmaceutical Development

Exploring New Paradigms for Bioprocessing

July
2009
SBE Special Section
Jonathan Monk
Disruptive technologies, such as disposable bioreactors, metabolic ?ux models, and glycoengineered yeast, could change the face — and pace — of biomanufacturing.

The New Disposable Evolution

July
2009
SBE Special Section
Joanna Ziemlewski
Single-use systems have advanced from a limited product line to several new products for a wider range of unit operations. As these technologies evolve, new size, cost, and regulatory needs continue to fuel industry growth.

Biobutanol – A Replacement for Bioethanol?

August
2008
SBE Special Section
Ron Cascone
Ethanol, the leading incumbant biofuel, has several limitations.Butanol overcomes many of these, and holds promise as the next important transportation biofuel.

Producing Fuels and Chemicals from Lignocellulosic Biomass

August
2008
SBE Special Section
Mark Holtzapple, Rocio Sierra, Aaron Smith, Cesar Granda and Mark T. Holtzapple
As oil and natural gas prices rise, lignocellulosic biomass becomes a viable feedstock for the fuel and chemical industries— provided key issues are addressed.

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