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Chemical Engineering Perspectives on Vaccine Production

November
2011
SBE Special Section
Bret R. Phillips, John G. Aunins, Jose M. Otero, Michael E. Laska
Fundamental chemical and bioprocess engineering principles and tools will be key to developing and manufacturing vaccines and expanding their availability around the world.

Algal Biofuels: The Backstory

March
2011
SBE Special Section
Arjun Gopalratnam
Increasing energy demand and dwindling energy resources have spurred interest in making transportation fuels from renewable sources such as microalgae.

Algal Biofuels: The Process

March
2011
SBE Special Section
Al Darzins, Eric P. Knoshaug
The production of algal biofuels involves algae cultivation, biomass harvesting and dewatering, lipid extraction, and conversion to fuel.

Algal Biofuels: The Research

March
2011
SBE Special Section
Kimberly Ogden, Kuan-Chen Cheng
The individual technical elements of the algae-to-biofuels process have already been demonstrated at the laboratory scale. Ongoing research seeks to refine the technology to enable scaleup to commercial production.

Stem Cell Engineering 101

November
2010
SBE Special Section
Jonathan Monk
Stem cells are poised to transform medical treatments for a host of diseases and malignant conditions. Translating stem cell research into clinical therapies, disease models, and drug-screening platforms will require a combination of sound science...

Engineering a Better Way to Heal Broken Bones

November
2010
SBE Special Section
Matthew B. Murphy
Integrating mesenchymal stem cells and biomaterials shows promise for treating traumatic skeletal injuries via bone tissue engineering.

Scaling Up Research to Commercial Manufacturing

November
2010
SBE Special Section
Erika Lapinskas
The production of stem-cell-based therapeutic products in large quantities is more complex than manufacturing molecular drugs. Scale-up and scale-out challenges arise related to the type of stem cell, cell expansion and banking, sterile handling,...

Developing Cell Therapy Biomanufacturing Processes

November
2010
SBE Special Section
Jon A. Rowley
Establishing scalable technology platforms that allow for varying levels of production throughout the different stages of clinical testing can minimize process development timelines, drug-comparability risks, and — ultimately — costs.

Converting Cellulose to Biofuels

March
2010
SBE Special Section
David Hogsett, Eduardo Ximenes, Michael R. Ladisch, Nathan S. Mosier, Youngmi Kim
Biochemical and thermochemical process technologies being developed to convert wood and other lignocellulosic feedstocks to liquid fuels will drive the transition from corn-based ethanol to advanced biofuels.

The Role for Biofuels

March
2010
SBE Special Section
Carrie Atiyeh, Tim Eggeman
The advanced biofuels industry is at a critical stage of development and deployment.

Minimize Scale-Up Risk

March
2010
SBE Special Section
Bertil Stromberg, J. Brad Cort, Thomas Pschorn
Proven commercial-scale equipment already exists for many operations involved in producing biofuels from lignocellulosic feedstocks.

Ionic Liquid Pretreatment

March
2010
SBE Special Section
Blake A. Simmons, Bradley M. Holmes, Harvey W. Blanch, Seema Singh
Ionic liquids show promise as lignocellulosic biomass solvents. But is this approach a scientific curiosity or a commercially viable biofuel pretreatment technology?

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