An Introduction to Immunity and Vaccines

November
2011
SBE Special Section
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Derek Lapiska
An understanding of the basic approach to creating vaccines, as well as how vaccines confer immunity, is essential to developing safe and cost-effective formulations.

Chemical Engineering Perspectives on Vaccine Production

November
2011
SBE Special Section
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John G. Aunins
Michael E. Laska
Bret R. Phillips
Jose M. Otero
Fundamental chemical and bioprocess engineering principles and tools will be key to developing and manufacturing vaccines and expanding their availability around the world.

SBE Update

March
2011
SBE Special Section
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Miriam Cortes-Caminero

Algal Biofuels: The Backstory

March
2011
SBE Special Section
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Arjun Gopalratnam
Increasing energy demand and dwindling energy resources have spurred interest in making transportation fuels from renewable sources such as microalgae.

Algal Biofuels: The Process

March
2011
SBE Special Section
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Eric P. Knoshaug
Al Darzins
The production of algal biofuels involves algae cultivation, biomass harvesting and dewatering, lipid extraction, and conversion to fuel.

Algal Biofuels: The Research

March
2011
SBE Special Section
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Kimberly Ogden
Kuan-Chen Cheng
The individual technical elements of the algae-to-biofuels process have already been demonstrated at the laboratory scale. Ongoing research seeks to refine the technology to enable scaleup to commercial production.

Engineering a Better Way to Heal Broken Bones

November
2010
SBE Special Section
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Matthew B. Murphy
Integrating mesenchymal stem cells and biomaterials shows promise for treating traumatic skeletal injuries via bone tissue engineering.

Scaling Up Research to Commercial Manufacturing

November
2010
SBE Special Section
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Erika Lapinskas
The production of stem-cell-based therapeutic products in large quantities is more complex than manufacturing molecular drugs. Scale-up and scale-out challenges arise related to the type of stem cell, cell expansion and banking, sterile handling,...

Developing Cell Therapy Biomanufacturing Processes

November
2010
SBE Special Section
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Jon A. Rowley
Establishing scalable technology platforms that allow for varying levels of production throughout the different stages of clinical testing can minimize process development timelines, drug-comparability risks, and — ultimately — costs.

Stem Cell Engineering 101

November
2010
SBE Special Section
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Jonathan Monk
Stem cells are poised to transform medical treatments for a host of diseases and malignant conditions. Translating stem cell research into clinical therapies, disease models, and drug-screening platforms will require a combination of sound science...

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