This course presents the fundamentals of biomanufacturing. It focuses on the unit operations utilized to manufacture biological drug products. After an overview of product types, processes, and current Good Manufacturing Practice you’ll address the maintenance of cell lines and growth of cells in a bioreactor. Topics such as mass transfer, process control, and product expression are emphasized. In the second half of the course, lectures focus on downstream unit operations that harvest cells, remove byproducts or contaminants, and fill the final bulk product.
This course was developed in conjunction with the Biomanufacturing Training and Education Center (BTEC) at NC State and SBE.
Topics will include:
- Why and how biopharmaceutical production is regulated
- Typical biomanufacturing flow
- Cryopreservation
- Basics of metabolism and nutrition requirements
- Examples of yield calculations
- Cell growth for industrial production
- Non-suspension cultures
- Solid-liquid separation
- Gravity sedimentation vs. centrifugation
- Centrifuge process and performance parameters
- Chromatography techniques by separation mechanism
- Viral clearance methods
- The ultimate goal of ultrafiltration/diafiltration (UF/DF):
- protein concentration, buffer exchange
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Please see the BTEC Directory for more information on authors.
Pricing
| AIChE Members | $795 |
| AIChE Grad Student Members | $397.50 |
| AIChE Undergrad Student Members | $397.50 |
| Non-Members | $995 (Membership is just $199 a year. For more information on becoming an AIChE member click here.) |
Questions? Check out the Frequently Asked Questions or email us at edu@aiche.org