A Bottom Up Approach to Systems Biotechnology – Lessons Learned from Bacterial Signal Transduction

SBE Webinar
Originally delivered Dec 8, 2009

Bacterial quorum sensing offers an interesting viewpoint from which to study and control cell phenotype. Through the perception of signal molecules (e.g., AHL, AI-2) and their transduction, bacteria coordinate their behavior and act as multicellular units. This coordination is responsible for establishing virulence among a variety of pathogens. A combination of negative (auto-regulation) and positive feedback mechanisms that control the flow of information can be examined by separating the network architecture into sub-networks. Biofabricated devices that report on signaling events are constructed to elucidate cell-cell communication and serve as a foundation upon which to develop new drugs and/or screen for pathogenic phenotype. Using bottom up approaches such as those we have developed will improve our chances to sense and intercept communication in pathogenic bacteria and prevent the spread of infectious diseases.

Professional Development Hours
1.0 PDHs
You will be able to download and print a certificate for these PDH credits once the content has been viewed. If you have already viewed this content, please click here to login.
Presenter(s): 

William E. Bentley

William E. Bentley is the Robert E. Fischell Distinguished Professor of Engineering and founding Chair of the Fischell Department of Bioengineering. He is also appointed in the Department of Chemical and Biomolecular Engineering at the University of Maryland, College Park and the Center for Biosystems Research of the University of Maryland Biotechnology Institute.

Would you like to access this content?

No problem. You just have to complete the following steps.

You have completed 0 of 2 steps.

  1. Log in

    You must be logged in to view this content. Log in now.

  2. Purchase Webinar

    You must purchase this webinar using one of the options below.
    If you already purchased this content recently, please click here to refresh the system's record of ownerships.

Pricing

Credits 1 Use credits
List Price $99.00 Buy now
AIChE Members $69.00 Buy now
AIChE Undergraduate Student Members Free Free access
AIChE Graduate Student Members Free Free access
SBE Members Free Free access
Webinar content is available with the kind permission of the author(s) solely for the purpose of furthering AIChE’s mission to educate, inform and improve the practice of professional chemical engineering. All other uses are forbidden without the express consent of the author(s). For permission to re-use, please contact chemepermissions@aiche.org.