Biomaterials for Stem Cell Tissue Engineering

SBE Webinar
Originally delivered Apr 5, 2011

Stem cells have become a promising cell source in the tissue engineering field. Intense studies have been focused at the cell and molecular biology levels on understanding the relationship between stem cell growth and terminal differentiation in an effort to control these processes. Recent discoveries have shown that the microenvironment can influence stem cell self-renewal and differentiation, which has had a tremendous impact on identifying potential strategies for using these cells effectively in the body. This presentation will describe studies examining the influence of biomaterials on stem cell behavior with an emphasis on identifying biomaterials designs and chemistries that impart appropriate cues to stem cells to affect their behavior both in vitro and in vivo. Specifically, surface wettability can influence stem cell osteogenesis, which is relevant for bone repair applications.

Hydrophobic polymers and their use with bioactive ceramics to create bioactive composites have been identified to greatly enhance the expression of bone cell markers. Biomaterial design such as fiber and pore size dimension can also greatly influence differentiation. Studies using polymers having fiber dimensions varying from the nano to micron-scale influenced chondrogenic differentiation of stem cells. The resulting changes in pore size also had a significant effect, but variations in mechanical properties played a minor role. The effect of electromechanical properties of polymeric materials, specifically piezoelectric polymers, on stem cell differentiation along bone, cartilage and neural lineages will also be discussed. Current results with their use in vivo will be presented.

Professional Development Hours
1.0 PDHs
You will be able to download and print a certificate for these PDH credits once the content has been viewed. If you have already viewed this content, please click here to login.
Presenter(s): 

Dr. Treena Arinzeh

Dr. Arinzeh received her B.S. from Rutgers University, New Brunswick, NJ in Mechanical Engineering, her M.S.E. in Biomedical Engineering from JohnsHopkinsUniversity, and her Ph.D. in Bioengineering from the University of Pennsylvania.  She worked for several years as a project manager at a stem cell technology company, Osiris Therapeutics, Inc.  Dr. Arinzeh joined the faculty of the New Jersey Institute of Technology (NJIT) in 2001 as one of the founding faculty members of the department of Biomedical Engineering.  Her most notable or cited work to date has been in the use of allogeneic...

Would you like to access this content?

No problem. You just have to complete the following steps.

You have completed 0 of 2 steps.

  1. Log in

    You must be logged in to view this content. Log in now.

  2. Purchase Webinar

    You must purchase this webinar using one of the options below.
    If you already purchased this content recently, please click here to refresh the system's record of ownerships.

Pricing

Credits 1 Use credits
List Price $99.00 Buy now
AIChE Members $69.00 Buy now
AIChE Undergraduate Student Members Free Free access
AIChE Graduate Student Members Free Free access
SBE Members Free Free access
Webinar content is available with the kind permission of the author(s) solely for the purpose of furthering AIChE’s mission to educate, inform and improve the practice of professional chemical engineering. All other uses are forbidden without the express consent of the author(s). For permission to re-use, please contact chemepermissions@aiche.org.