In this work, we present the results and case studies from the Engineering Research Center for Structured Organic Particulate Systems (ERC-SOPS), in developing a real-time process management system for continuous pharmaceutical manufacture, that makes use of an ontological informatics framework to manage process knowledge of multiple types, including material properties (such as stress-density relationships), process parameters (such as process setpoints), equipment parameters (such as die and punch sizes in a tablet press), and process control knowledge (mathematical models for PID and model predictive control, process signatures for fault diagnosis, mathematical models to plan future setpoint changes, etc). The models taken together operate on a wide range of time scales, and the knowledge management framework is designed to be flexible for all uses. Further, we show how the system architecture allows for the use of various control systems and modeling programs in a flexible manner. Finally, we present case studies in tablet manufacturing and drop-on-demand systems, and summarize our current results.
Would you like to access this content?
No problem. You just have to complete the following steps.
You have completed 0 of 2 steps.
You must be logged in to view this content. Log in now.
Purchase Technical Presentation
You must purchase this technical presentation using one of the options below.
If you already purchased this content recently, please click here to refresh the system's record of ownerships.
|Credits||0.5 Use credits|
|List Price||$25.00 Buy now|
|AIChE Members||$15.00 Buy now|
|AIChE Undergraduate Student Members||Free Free access|
|AIChE Graduate Student Members||$15.00 Buy now|