Real-Time Monitoring of Continuous Processes with Spectroscopic PAT-Tools

Comprehensive Quality by Design in Pharmaceutical Development and Manufacture
2010 AIChE Annual Meeting
AIChE Annual Meeting
November 9, 2010 - 7:00pm
The aim of Process Analytical Technology (PAT) is to gain deeper insight in pharmaceutical manufacturing processes, replacing empirical approaches by knowledge-based procedures. A detailed understanding of the key parameters of a process and their impact on the product quality allows companies to “build in quality” instead of “testing it into the final product”. From this point of view, PAT has to be tailored for a direct implementation to manufacturing lines to measure in real-time the key parameters of the process. Here, we present results on real-time quantitative in-line monitoring of powder mixing processes by near-infrared (NIR) spectroscopy [1, 2]. Spectral data collection and data analysis was performed in real-time based on partial least squares models developed via dynamic calibration. Different strategies are followed: I) Application of a single reflection probe to determine the mixing end-point. II) A novel multiple reflectance probe measurement system for a spatially resolved monitoring of the powder flow kinetics within a blender. The parameters from the mixing process are linked to keyparameters of powders, obtained from rheometric investigations based on experimental design. Beside the batch processes monitored here with NIR spectroscopy, we also introduce hyper spectral imaging for monitoring fast continuous processes and non-invasive product quality analysis of solid dosage forms. [1] Koller D M, Posch A, Hörl G, Voura C, Radl S, Urbanetz N, Fraser S D, Tritthart W, Reiter F, Schlingmann M, Khinast J G. Continuous Quantitative Monitoring of Powder Mixing Dynamics by Near-infrared Spectroscopy. Powder Technology 2010; submitted [2] Remy B, Glasser B J, Khinast J G. The effect of mixer properties and fill level on granular flow in a bladed mixer. AIChE Journal 2010, 56: 336-353. doi:10.1002/aic.11979
Professional Development Hours
0.5 PDHs
You will be able to download and print a certificate for these PDH credits once the content has been viewed. If you have already viewed this content, please click here to login.
Presenter(s): 

Would you like to access this content?

No problem. You just have to complete the following steps.

You have completed 0 of 2 steps.

  1. Log in

    You must be logged in to view this content. Log in now.

  2. Purchase Technical Presentation

    You must purchase this technical presentation using one of the options below.
    If you already purchased this content recently, please click here to refresh the system's record of ownerships.

Pricing

Credits 0.5 Use credits
List Price $25.00 Buy now
AIChE Members $15.00 Buy now
AIChE Undergraduate Student Members Free Free access
AIChE Graduate Student Members Free Free access
Skill Level: