Stem Cell Engineering Conference Program
Preliminary Program
| Sunday, May 2 | |
| 5:30PM-6:30PM | Welcome Reception |
| 6:30PM-10:00PM | Dinner |
| 6:30PM-6:45PM | Introductory Remarks: George Daley, Harvard University and Peter Zandstra, University of Toronto |
| 6:45PM-7:15PM | A Network Biology Approach to Stem Cell Engineering James J. Collins, Boston University Keynote Presentation |
| 7:15PM-7:45PM | Design Principles of Pluripotency Austin Smith, Cambridge University Keynote Presentation |
| Monday, May 3 | |
| 8:30AM-9:45AM | Session 1: High Throughput and Microfluidic Screening Platforms Chairs: Sangeeta Bhatia, Massachusetts Institute of Technology and Joel Voldman, Massachusetts Institute of Technology |
| 8:30AM-9:00AM | High throughput microfluidics platforms for neuroscience and systems biology Hang Lu, Georgia Institute of Technology Invited Presentation |
| 9:00AM-9:15AM | Microfluidics-Integrated Time-Lapse Imaging for Analysis of Cellular Dynamics Jagesh Shah, Harvard-Massachusetts Institute of Technology |
| 9:15AM-9:30AM | Nanovolume Bioreactors Optimized to Match Macroscale Culture Performance and Allow High-Throughput Assessment of Heterogeneity in Hematopoietic Stem Cell Populations James M. Piret, University of British Columbia |
| 9:30AM-9:45AM | A Microfluidic Platform for the Spatial-Temporal Generation of Infarcted Heart Conditions: Highthroughput Screening On Human Embryonic Stem Cells-Derived Cardiomyocytes Elisa Cimetta, University of Padova |
| 9:45AM-10:05AM | Break |
| 10:05AM-12:05PM | Session 2: iPS Cell Programming and Diesease Models Chairs: Mahendra Rao, Ivtn and Stephen Oh, Singapore |
| 10:05AM-10:35AM | Stem Cell Engineering for Drug Discovery Lee Rubin, Harvard University Invited Presentation |
| 10:35AM-10:50AM | Mesenchymal Stem Cell Dysfunction in An iPSC –Derived Model of Human Progeria Alan Colman, A*STAR Institute of Medical Biology |
| 10:50AM-11:05AM | Efficient Generation of Functional Dopaminergic Neurons From Human Induced Pluripotent Stem Cells Under Defined Conditions Xianmin Zeng, Buck Institute for Age Research |
| 11:05AM-11:20AM | The Nuclear Receptor Nr5a2 Can Replace Oct4 in the Reprogramming of Murine Somatic Cells to Pluripotent Cells Huck-Hui Ng, Genome Institute of Singapore |
| 11:20AM-12:05PM | Molecular Elucidation and Engineering of Stem Cell Microenvironments David Schaffer, UC Berkley Keynote Presentation |
| 12:05PM-1:30PM | Lunch |
| 1:30PM-2:45PM | Session 3: Novel Approaches for Adult Stem Cell Growth and Differentiation |
| 1:30PM-2:00PM | Targeting the niche to restore function to aged stem cells Amy Wagers, Harvard University Invited Presentation |
| 2:00PM-2:15PM | ECM-Functionalized Microcavity Arrays to Explore Fate Decisions in Hematopoietic Stem Cells Carsten Werner, Leibniz Institute of Polymer Research Dresden |
| 2:15PM-2:30PM | Engineering Three-Dimensional Stromal Tissues Ivan Martin, University Hospital Basel |
| 2:30PM-2:45PM | Substrate Elasticity Regulates Murine Skeletal Muscle Stem Cell Self Renewal in Culture Karen Havenstrite, Stanford University |
| 2:45PM-3:05PM | Break |
| 3:05PM-3:35PM | Session 4: Endogenous Repair Chairs: Anand Asthagiri, Cal Tech and Carsten Werner, Dresden University |
| 3:05PM-3:35PM | Cellular constituents of the hematopoietic stem cell niche Paul Frenette, Mount Sinai School of Medicine Invited Presentation |
| 3:35PM-4:05PM | Programming Cells In Situ Using Polymers David Mooney, Harvard University Invited Presentation |
| 4:05PM-4:20PM | Development of Osteogenic Scaffolds with Prospectively Isolated Adult Mesenchymal Stem Cells for Endogenous Bone Repair Matthew B. Murphy, University of Texas Health Science Center - Houston |
| 4:20PM-4:35PM | The In Vivo Bioreactor: A Unique Paradigm for De Novo Tissue Engineering V. Prasad Shastri, University of Freiburg |
| 4:35PM-4:50PM | Nano-Topographically Defined Scaffolds for Heart Regeneration and Repair Andre Levchenko, Johns Hopkins University |
| 4:50PM-6:30PM | Poster Session with Refreshments |
Free Night for Dinner |
|
| Tuesday, May 4 | |
| 8:30AM-9:45PM | Session 5: Intercellular Signaling and the Engineered Niche Chairs: Christopher Chen, University of Pennsylvania and John Aunins, Merck |
| 8:30AM-9:00AM | Matrix and Myosin in cell fate decisions: MSCs, HSCs, and Embryonic Cardiomyocytes Dennis Discher, University of Pennsylvania Invited Presentation |
| 9:00AM-9:15AM | Tissue Geometry and Epithelial-Mesenchymal Transition Celeste M. Nelson, Princeton University |
| 9:15AM-9:30AM | Perfusion Primes Mouse Embryonic Stem Cells for Differentiation in a Self-Renewing Environment Via Shear Stress Yi-Chin Toh, Massachusetts Institute of Technology |
| 9:30AM-9:45AM | Cell Geometry and Adhesive Chemistry Influences Mesenchymal Stem Cell Lineage Commitment Kristopher Kilian, University of Chicago |
| 9:45AM-10:05AM | Break |
| 10:05AM-12:05PM | Session 6: Bioreactors and Bioprocesses for Cell Expansion and Differentiation Chairs: Jamie Piret, University of British Columbia and Joaquim Cabral, IST Portugal |
| 10:05AM-10:35AM | Stem Cell Engineering – Toward Stem Cell Bioprocesses Wei-Shou Hu University of Minnesotta Invited Presentation |
| 10:35AM-10:50AM | Effect of Hypoxia On Proliferation and Neural Commitment of Embryonic Stem Cells at Different Stages of Pluripotency Tiago G. Fernandes, Instituto Superior Técnico |
| 10:50AM-11:05AM | Expansion and Directed Differentiation of Human Pluripotent Stem Cells in Scalable Stirred-Suspension Bioreactors Emmanuel (Manolis) S. Tzanakakis, State University of New York at Buffalo |
| 11:05AM-11:20AM | Versatile Microcarrier Systems for Enhancing hESC Expansion and Cardio-Differentiation Steve Oh, Bioprocessing Technology Institute |
| 11:20AM-12:05PM | Repairing the Infarcted Heart with Engineered Human Myocardium Chuck Murry, University of Washington Keynote Presentation |
| 12:05PM-1:30PM | Lunch |
| 1:30PM-2:45PM | Session 7: Systems-Based Approaches to Understanding Fate Devisions |
| 1:30PM-2:00PM | Heterogeneity and flexibility of cell fate decisions - A conceptual perspective Ingo Roeder, University of Lipzig Invited Presentation |
| 2:00PM-2:15PM | Constrained Fuzzy Logic: a Novel Methodology for Training Predictive, Quantitative Biomolecular Signaling Network Models Melody Morris, Massacusetts Institute of Technology |
| 2:15PM-2:30PM | Subpopulation Tracking of Human Pluripotent Stem Cells Screened in Controlled Microenvironments Reveals Signalling Cues Regulating the Early Lineage Differentiation Tree Emanuel J.P. Nazareth, University of Toronto |
| 2:30PM-2:45PM | Quantitative Models of Reprogramming Somatic Cells to Pluripotency Krishanu Saha, Whitehead Institute for Biomedical Research |
| 2:45PM-3:05PM | Break |
| 3:05PM-4:50PM | Session 8: Translating Stem Cells Towards the Clinic Chairs: Matthias Lutolf, Ecole Polytechnique Federale de Lausanne and Sharon Gerecht, Johns Hopkins University |
| 3:05PM-3:35PM | Cancer Stem Cells – Lessons from Leukemia Connie Eaves, TFL Vancouver Invited Presentation |
| 3:35PM-4:05PM | Combinatorial development of biomaterials for tissue engineering and drug delivery Daniel Anderson, Massachusetts Institute of Technology Invited Presentation |
| 4:05PM-4:20PM | Mechanobiology of Glioblastoma: Lessons Learned and Implications for Brain Tumor Stem Cells Sanjay Kumar, University of California, Berkeley |
| 4:20PM-4:35PM | Engineering the Perivascular Niche to Study Brain Cancer Tumorigenesis Claudia Fischbach, Cornell University |
| 4:35PM-4:50PM | Bone Marrow Niche-Inspired, Multi-Phase Expansion of Megakaryocytic Progenitors and Mature Megakaryocytic Cells with High Polyploidization Potential William M. Miller, Northwestern University |
| 4:50PM-6:30PM | Poster Session with Refreshments Chairs: Julie Audet, University of Toronto, Jeff Karp, Massachusetts Institute of Technology, Taby Ahsan, Tulane University, Jon Rowley, Lonza Group Ltd. |
Free Night for Dinner |
|
| Wednesday, May 5 | |
| 8:30AM-9:45AM | Session 9: Tissue Engineering and Regeneration using Stem Cells Chairs: Todd McDevitt, Georgia Institute of Technology and Jennifer Elisseeff, Johns Hopkins University |
| 8:30AM-9:00AM | Dynamically Tunable Scaffolds to Direct Cell Function and Tissue Regeneration Kristi Anseth, University of Colorado Invited Presentation |
| 9:00AM-9:15AM | Engineered Heart Tissue Enables Interrogation of Regenerative Potential of Injected Pluripotent Stem Cells and Their Derivatives Milica Radisic, University of Toronto |
| 9:15AM-9:30AM | Stem Cell-Derived 3-Dimensional Heart Tissues with Advanced Electromechanical Function Nenad Bursac, Duke University |
| 9:30AM-9:45AM | Generating Epithelial Tissues From Human Pluripotent Stem Cells Sean P. Palecek, University of Wisconsin - Madison |
| 9:45AM-10:05AM | Break |
| 10:05AM-12:25PM | Session 10: Novel Approaches for Pluripotent Stem Cell Growth and Differentiation Chairs: Ralph Brandenberger, Geron Corporation and Sean Palecek, University of Wisconson |
| 10:05AM-10:35AM | Directed differentiation of pluripotent stem cells Gordon Keller ,University of Toronto Invited Presentation |
| 10:35AM-10:50AM | Effect of Shear Stress Parameters On Differentiation of Escs to Hematopoetic and Endothelial Phenotypes Taby Ahsan, Tulane University |
| 10:50AM-11:10AM | Engineering the Differentiation of Embryoid Bodies in Suspension Culture Todd C. McDevitt, Georgia Institute of Technology / Emory University |
| 11:10AM-11:25AM | Up Scaling Single Cell-Inoculated Suspension Culture of Human Embryonic Stem Cells Robert Zweigerdt, Hannover Medical School (MHH) |
| 11:25AM-11:55PM | Stem cells to create a pancreas and recreate human Type1 diabetes Doug Melton, Harvard University Keynote Presentation |
| 11:55PM-12:25PM | Engineering Human Tissues Gordana Vunjak-Novakovic, Columbia University Keynote Presentation |
| 12:25PM-12:30PM | Closing Remarks by George Daley, Children's Hospital, Harvard Medical School and Peter Zandstra, University of Toronto |
| Box Lunch Departure | |
Posters board dimensions are 4'x8'. Posters will be in the Michelangelo and Olympia Rooms.
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