CEP: March 2013

The SBE supplement on drug delivery explores some emerging technologies for drug delivery. Other topics this month include Coriolis meters, process flow failure mode (PFFM) analysis and licensure as a professional engineer. Also read about the latest developments in materials, nanotechnology, biotechnology, and Energy.

Editorial

Many of us remember receiving our polio vaccine on a sugar cube. Indeed, that was the motivation behind A Spoonful of Sugar, a song from the classic Disney movie Mary Poppins. Walt Disney had instructed the Sherman brothers, Robert and Richard, to come up with a catchy song for the film. When Robert arrived at home, after working all day trying to come up with an idea, his wife told him that the children had gotten their polio vaccine that day. Thinking they had gotten a shot, he asked them if it hurt. His son answered that the medicine was put on a cube of sugar and he swallowed it. And so “a spoonful of sugar helps the medicine go down” was born.

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Coriolis: The Direct Approach to Mass Flow Measurement

March
2013
Back To Basics
Tom O’Banion
Coriolis meters eliminate the need to measure and correct for pressure, temperature, and density fluctuations to determine mass flowrate. Although their capital costs may be higher, they typically have a lower overall cost of ownership than other types of meters

Assess Hazards with Process Flow Failure Modes Analysis

March
2013
Safety
Rosalynn MacGregor
Process flow failure modes (PFFM) analysis is an intuitive, process-flow-directed way to identify potentially hazardous scenarios. Learn how to apply this technique to your process hazard reviews.

SBE Update: Drug Delivery and Chemical/Biological Engineering

March
2013
SBE Special Section
June Wispelwey
Although you might not associate drug delivery with chemical engineering, the principles of chemical engineering — such as mass and energy balances, transport phenomena, reaction kinetics, and particle technology — are intimately involved in drug...

Introduction to Drug Delivery Technology

March
2013
SBE Special Section
John T. Santini, Jr.
Drugs can be administered by many routes, yet all emerging drug delivery technologies aim to improve drug efficacy, minimize side effects, and reduce the burden of care for patients and physicians.

Engineering Biodegradable Nanoparticles for Drug and Gene Delivery

March
2013
SBE Special Section
Junwei Zhang
Engineered nanoparticles can deliver therapeutic agents to specifically targeted cells and then release those agents in a precisely controlled manner. Improved pharmacokinetic properties, reduced toxicity, and the ability to cross biological barriers are some of the key benefits of this approach.

The Blood-Brain Barrier and Drug Delivery

March
2013
SBE Special Section
William Olbricht
To maintain favorable conditions in the brain, the blood-brain barrier limits mass transfer across brain tissue. However, it also restricts the systemic delivery of compounds to treat neurological disorders. Several treatment alternatives to bypass...

Bioactive Devices: Uniting Form with Function

March
2013
SBE Special Section
Sujata Bhatia
Bioactive implants that combine a medical device with one or more biologic therapeutic agents show promise for the targeted treatment of complex medical conditions. Implantable medical devices, such as stents, grafts, and joint replacements, are...
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