Understanding Micro Environmental Thermodynamics of Tablet Coating Process Using Data Logger ? Case Studies

Pharmaceutical Discovery, Development and Manufacturing Forum
AIChE Annual Meeting
November 5, 2013 - 9:00am-9:15am

Pharmaceutical film coating process is typically monitored by inlet and exhaust temperature and humidity conditions , with measurement devices located outside the coating pan. Current configurations of coating pans does not allow continuous measurement of the temperature and humidity within the tablet bed. Measurable differences in heat and mass transfer efficiencies across coating pan sizes and designs can result in different drying and film forming dynamics at the same measured outlet temperature and humidity. Similarly , different microenvironment (temperature and humidity conditions inside the tablet bed) and hence film forming dynamics can be expected for coating operations carried out at the same exhaust temperature , if this temperature is achieved by changes to the process parameters such as inlet air volume , air temperature , suspension spray rate or suspension solids concentration. Considerable insight into the dynamics of the coating process can be gained if data loggers can be incorporated in the tablet bed and placed such that they can collect temperature and humidity conditions in the tablet bed continuously. Two case studies will be presented where the micro-environmental data from PyroButtons provide meaningful correlation to coated tablet defects. The authors will show that this data can be used to establish a process design space for a given coating and tablet formulation. The first case study is a full factorial design of experiments (DOE) on three process parameters; exhaust temperature , pan speed and spray rate conducted on a 24 inch pan coater , that showed correlation of micro environmental conditions to coated tablet appearance. The second case study will show correlation between delamination tendency of a bilayer tablet and tablet-bed micro environment.

Professional Development Hours
0.5 PDHs
You will be able to download and print a certificate for these PDH credits once the content has been viewed. If you have already viewed this content, please click here to login.
Presenter(s): 

Would you like to access this content?

No problem. You just have to complete the following steps.

You have completed 0 of 2 steps.

  1. Log in

    You must be logged in to view this content. Log in now.

  2. Purchase Technical Presentation

    You must purchase this technical presentation using one of the options below.
    If you already purchased this content recently, please click here to refresh the system's record of ownerships.

Pricing

Credits 0.5 Use credits
List Price $25.00 Buy now
AIChE Members $15.00 Buy now
AIChE Undergraduate Student Members Free Free access
AIChE Graduate Student Members Free Free access
Skill Level: