Precise Monomeric Control of Multicomponent Random Copolymers: Excipient Design for Oral Drug Delivery

Pharmaceutical Discovery, Development and Manufacturing Forum
AIChE Annual Meeting
November 7, 2013 - 9:36am-9:58am
Random copolymers (RCPs) are macromolecules composed of two or more monomers with desirable functionalities randomly distributed along the polymer backbone. These compounds are instrumental to applications such as the oral delivery of poorly water-soluble drugs , where polymer-drug interplay governs the storage and delivery of active pharmaceutical ingredients. Although binary RCP systems have been studied extensively , there is currently very little guidance on understanding the kinetics of multicomponent copolymers , which are playing an ever-increasing role in imparting more unique physical properties. Herein , we demonstrate a systematic approach for simultaneously targeting exact molecular weights and chemical compositions of multimonomeric RCPs using reversible addition-fragmentation chain transfer free-radical (RAFT) polymerization. An illustrative system to showcase this procedure was studied and compared to a well-known macromolecule utilized in oral drug delivery (HPMCAS , or hydroxypropyl methyl cellulose acetate succinate. The relative reactivities at 70°C between monomer pairs were measured and employed to predict the feed ratio necessary for synthesizing well-defined compositions based on the Walling-Briggs model. Application of the Skeist equations addressed compositional drift and anticipated the general monomer incorporation distribution as a function of conversion , which was verified experimentally. This simple “controlled statistics” paradigm provides complementary synthetic and predictive tools for designing macromolecular chemical architectures with hierarchical control over spatially-dependent structure-property relationships for complex applications such as oral drug delivery.
Professional Development Hours
0.5 PDHs
You will be able to download and print a certificate for these PDH credits once the content has been viewed. If you have already viewed this content, please click here to login.

Would you like to access this content?

No problem. You just have to complete the following steps.

You have completed 0 of 2 steps.

  1. Log in

    You must be logged in to view this content. Log in now.

  2. Purchase Technical Presentation

    You must purchase this technical presentation using one of the options below.
    If you already purchased this content recently, please click here to refresh the system's record of ownerships.


Credits 0.5 Use credits
List Price $25.00 Buy now
AIChE Members $15.00 Buy now
AIChE Undergraduate Student Members Free Free access
AIChE Graduate Student Members Free Free access
Related Topics: 
Skill Level: