Latent variable regression models (LVRMs) are tools specifically designed to analyze large datasets of highly correlated data reducing the vast information in them in a small number of variables (the latent variables) which indentify the underlying driving forces relating input data with system outputs. The driving forces identified from the available historical databases represented by the LVRM equations can then be used to support the design of new products: since the design activity aims at finding the best combination of inputs (raw material properties and process conditions) which ensure a desired product profile in output, the design objectives could be achieved through a LVRM inversion operation.
In this contribution we show how LVRM inversion [1,2] can be feasibly used to support pharmaceutical product and process development activities. Since the LVRM inversion can have several solutions depending on the rank of the historical datasets used to build the model, the inversion has to be posed as an optimization problem [3,4]. A framework is therefore proposed to manage the different constraints and objectives the design problem may have, in order to solve in each situation the most appropriate LVRM inversion problem.
The proposed procedure is tested on two different product design applications, related to a particle engineering problem for the design of a wet granulated product of desired properties and to the selection of the best formulation for a given API, in order to obtain blends suitable for direct compression. In both cases the LVRM inversion is shown to be very effective in estimating the best inputs to obtain the desired product in output, giving a systematic tool to guide experiments since the first stages of development for the establishment of the system design space.
 Jaeckle, C. M. and J. F. MacGregor (1998). Product design through multivariate statistical analysis of process data. AIChE J., 44, 1105-1118.
 Jaeckle, C. M. and J. F. MacGregor (2000). Industrial applications of product design through the inversion of latent variable models. Chemom. Intell. Lab. Sys., 50, 199-210.
 García-Muñoz, S., T. Kourti, J. F. MacGregor, F. Apruzzese and M. Champagne (2006). Optimization of batch operating policies. Part I. Handling multiple solutions. Ind. Eng. Chem. Res., 45, 7856-7866.
 García-Muñoz, S., J. F. MacGregor, D. Neogi, B. E. Letshaw and S. Mehta (2008). Optimization of batch operating policies. Part II. Incorporating process constraints and industrial applications. Ind. Eng. Chem. Res., 47, 4202-4208.
Would you like to access this content?
No problem. You just have to complete the following steps.
You have completed 0 of 2 steps.
You must be logged in to view this content. Log in now.
Purchase Technical Presentation
You must purchase this technical presentation using one of the options below.
If you already purchased this content recently, please click here to refresh the system's record of ownerships.
|Credits||0.5 Use credits|
|List Price||$25.00 Buy now|
|AIChE Members||$15.00 Buy now|
|AIChE Undergraduate Student Members||Free Free access|
|AIChE Graduate Student Members||$15.00 Buy now|