Dissolution of Different Commercial Aspirin Tablets Using a Novel Off-Center Paddle Impeller (OPI) Dissolution Testing System

Pharmaceutical Discovery, Development and Manufacturing Forum
AIChE Annual Meeting
November 7, 2013 - 4:30pm-5:00pm

Dissolution testing is routinely conducted in the pharmaceutical industry to provide in vitro drug release information for quality control purposes. The most common dissolution testing system for solid dosage forms is the United States Pharmacopeia (USP) Dissolution Testing Apparatus 2.  In this work , a modified Apparatus 2 , termed “OPI” System for “off-center paddle impeller ,” in which the impeller was placed 8 mm off center in the vessel was tested to determine its sensitivity to differentiate between the dissolution profiles of differently formulated and manufactured tablets.  Dissolution tests were conducted with both the OPI System and the Standard System using three different brands of aspirin at nine different tablet positions.  The OPI system produced dissolution profiles that were highly dependent on the different brands of aspirin used , similarly to those generated in the Standard System.  However , the dissolution profiles obtained with the OPI apparatus were found to be largely independent of the tablet location at the vessel bottom , whereas those obtained in the Standard System generated statistically different profiles depending on tablet location.  It can be concluded that the newly proposed OPI system can effectively eliminate artifacts generated by random settling of the tablet at the vessel bottom , thus making the test more robust , while at the same time being just as sensitive as the Standard System to actual differences in differently manufactured tablets having intrinsically different dissolution profiles.

Professional Development Hours
0.5 PDHs
You will be able to download and print a certificate for these PDH credits once the content has been viewed. If you have already viewed this content, please click here to login.

Would you like to access this content?

No problem. You just have to complete the following steps.

You have completed 0 of 2 steps.

  1. Log in

    You must be logged in to view this content. Log in now.

  2. Purchase Technical Presentation

    You must purchase this technical presentation using one of the options below.
    If you already purchased this content recently, please click here to refresh the system's record of ownerships.


Credits 0.5 Use credits
List Price $25.00 Buy now
AIChE Members $15.00 Buy now
AIChE Undergraduate Student Members Free Free access
AIChE Graduate Student Members Free Free access