Conference Presentations - 2010 AIChE Annual Meeting

Multivariate latent variable models (such as Principal Components Analysis –PCA, and Projection to Latent Structures –PLS) have been reported in literature to transform a collection of physical properties measured for multiple materials into scores (or principal properties) with the ultimate...

Transforming growth factor ß (TGF-ß), which plays a pivotal role in regulating a wide array of cellular and physiologic processes in both normal and pathological cells, is known to function as a potent tumor suppressor during the early stage of tumorigenesis, primarily by inhibiting cell...

Developing robust formulations for biological materials (proteins, antibodies, vaccines, etc.) requires the screening and analysis of a comprehensive matrix of formulation compositions and stress conditions. This talk will focus on the development and use of a fully-automated workflow for stressing...

Risk analysis and assessment tools are a key component of Quality by Design (QbD) because they facilitate understanding, identifying, and documenting of risks affecting drug product quality attributes. As stated in the ICH Q8 guidelines, the “design space” is where a process generates a product...

The recent developments in the energy and process industries have lead to more efficient, higher-temperature processes and compact equipment. By using small features such as micro-channels, pin fins or plate fins the length scale for which transport occurs is minimized and thus increases the heat...

Bioprocess design, development and manufacturing involve different goals and use different tools. At the design stage a cell-centric approach dominates. During development and especially later during manufacturing a process-centered perspective prevails as if biomanufacturing performance was...