Conference Presentations - 2010 AIChE Annual Meeting

Cell Population Heterogeneity and Mass Transport Dynamics Modulate Tissue Regeneration Processes

Nov 9, 2010

Kyriacos Zygourakis

A better understanding of the complex interplay between cell population dynamics and mass transport is necessary for overcoming the barriers that have slowed down the development of bioartificial tissues. In a recent publication [1], we presented the development of a multi-scale computational model...

Modeling and Analysis of the Retinoic Acid Induced Proliferation and Differentiation Program of HL-60

Nov 9, 2010

Ryan Tasseff

Understanding the molecular basis of differentiation programs is one of the grand unmet challenges facing modern cell-biology. In this study, we integrated computational and experimental network analysis to unravel the response of HL-60 human myeloblastic leukemia cells to Retinoic Acid (RA)...

Optimizing and Controlling High Value Processes Using the Principles of Quality-by-Design (QbD) Advanced Tools Such as Real-Time in-Situ Particle Characterization, in-Situ Mid-Infrared Spectrometry, and Reaction Calorimetry

Nov 9, 2010

Leen Schellekens

Quality by Design (QbD) is a concept applied to gain true process understanding utilizing tools such as Design of Experiment (DoE), Risk Management, and Process Analytical Technology (PAT). Utilization of these principles and tools not only allow the chemist, engineer, or formulator to optimize a...

Identification of Families of Signal Transduction Models Using Pareto Optimal Ensemble Techniques (POETs)

Nov 9, 2010

Anirikh Chakrabarti

Mathematical modeling of complex signal transduction and gene expression programs is an emerging tool for understanding disease mechanisms. However, conventional wisdom suggests that the data requirement to identify and validate complex mechanistic models is too large. Typically, it is not possible...

Real-Time Monitoring of Continuous Processes with Spectroscopic PAT-Tools

Nov 9, 2010

Daniel M. Koller

The aim of Process Analytical Technology (PAT) is to gain deeper insight in pharmaceutical manufacturing processes, replacing empirical approaches by knowledge-based procedures. A detailed understanding of the key parameters of a process and their impact on the product quality allows companies to “...

Gene Regulation by MAPK Substrate Competition

Nov 9, 2010

Yoosik Kim

Introduction Traditional view of pattern formation in the early Drosophila embryo is essentially one-dimensional: The anterior, posterior, and terminal systems initiate the formation of bands and stripes of gene expression along the AP axis; at the same time, the orthogonal gradient of Dorsal (Dl)...

In Silico Modeling of the Immune Response Network: Influenza Immune-Escape Strategies and Implications in Influenza Drug Research

Nov 9, 2010

Jason E. Shoemaker

Recent evidence suggests that an overly ambitious immune response may be the primary factor that determines influenza severity [1], yet the definition of what is a reasonable immune response remains vague. Seasonal influenza, alone, is responsible for approximately 30,000 deaths in the US each year...

Raman Spectroscopy Combined with Small and Wide Angle X-Ray Scattering as a Non Destructive Quality Control Tool for Powder Compression Analytics in Pharmaceutical Applications

Nov 9, 2010

Nicolas Heigl

This study evaluates the feasibility of a combined use of small-wide angle X-ray scattering (SWAXS) and Raman spectroscopy as a non-invasive process analytical tool (PAT) for the analysis of pharmaceutical granulation and compression procedures. Placebo formulations containing Lactose monohydrate (...

Solution-Grown CuInSe2 Nanowires for Low-Cost Photovoltaics

Nov 9, 2010

Chet Steinhagen

A semiconductor media that could be printed under ambient conditions by a roll-to-roll process on plastic substrates to fabricate photovoltaic devices (PVs) would greatly reduce the cost of solar cell manufacturing. One approach is to create “paints” or “inks” of nanocrystals that can be deposited...

Renewable Petrochemicals From Biomass by Catalytic Fast Pyrolysis

Nov 9, 2010

George W. Huber

Lignocellulosic biomass has tremendous potential as a feedstock to make renewable fuels and petrochemicals from biomass. The current impediment to the utilization of our biomass resources is that most processes to convert biomass are not currently economical because of long residence times, the...

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Conference Presentations - 2010 AIChE Annual Meeting

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