Conference Presentations - 2009 AIChE Annual Meeting

Purification of Recombinant Plant-Made Proteins From Corn by Ultrafiltration

Nov 10, 2009
Matthew Aspelund
The use of corn as an expression host is an attractive system for the production of plant-made proteins. The use of plants lowers upstream costs making downstream the significant production cost. For some proteins, crossflow ultrafiltration could be a lower cost alternative. The potential for doing...

Gram-Scale Isolation of IEC Charge Variants Using Displacement Chromotography

Nov 10, 2009
Ryan Hutchinson
The pharmacokinetic profiles of monoclonal antibody charge variants are poorly understood because they differ only slightly from the “main” antibody species, are low in abundance, and extremely difficult to isolate in pure pools for intensive in vitro and in vivo studies. Because of this, the...

Flowchart Methodology Utilizing Validated Process Models as the Foundation for a Quality-by-Design (QbD)-Based Approach for Pharmaceutical Unit Operations: Example Case Studies

Nov 10, 2009
Lisa Graham
A model-based process development methodology is described which uses a Quality by Design (QbD) approach to establish a manufacturing design space. A flowchart methodology is described that illustrates how to rationally step through process development, using fundamental and engineering models and...

Mixing Scale-Down Studies for the Scale-Up of Beer Fermentation

Nov 10, 2009
Alvin Nienow
Beer fermentations have traditionally been undertaken without the use of mechanical agitation with mixing being provided only by the CO2 evolved during the batch process. This approach has largely been maintained because of the belief in industry that rotating agitators would damage the yeast. In...

Commercial-Scale Energy Crop Production: Establishing Switchgrass in Tennessee

Nov 9, 2009
Timothy Rials
With the advancement of cellulosic ethanol technologies in recent years, more emphasis is being placed on the production of a sustainable supply of biomass for commercial scale facilities. These facilities will require significant supplies of biomass that will, in the southeast, come from private...

Designing Sustainable Options for Bioenergy Crops

Nov 9, 2009
Virginia Dale
Currently, the complexity and scale dependency of land-use decisions and their impacts are not understood, defined, or described with adequate clarity to enable policy makers to develop strategies to ensure a sustainable bioenergy future with acceptable environmental and socioeconomic consequences...

Enzymatic Bioprocessing of Cellulose in N-Methyl Morpholine Oxide/Water

Nov 9, 2009
John Collier
To enzymatically convert biomass to biorefinery feedstock, biofuels, or hydrogen an environmentally friendly solvent or process is needed to disrupt the microstructure of lignocellulosics. In multi-stage processes, solvents are being used as pretreatments by dissolving cellulose and precipitation...

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