2011

Metabolic engineering has evolved to the point of fulfilling the dream of having our industrial chemicals produced renewably. Carboxylic acids (e.g., short chain fatty acids (SCFAs) such as octanoic acid (C8)) are one such chemical intermediate that can be produced with Escherichia coli engineered...

QbD is a systematic approach to pharmaceutical development and product lifecyclemanagement. QbD provides new opportunities and modern tools to utilize in analytical research and development. ICH guidelines and implementation strategies focused mainly on formulation and manufacturing design and...

This study reports the development of a Ni based oxygen carrier and the investigation of an Integrated Gasification (IG) and Combustion of solid biomass as a fuel for Chemical-Looping Combustion (CLC). The aim is to develop a highly reactive, stable and fluidizable oxygen carrier (OC): a cobalt (Co...

I will describe my participation over the past few years in an effort to find fundamental mathematical laws in biology. I will discuss a theory for understanding the emergence of multi-scale, hierarchical structure in biology. I will describe how modular structure in proteins, genetics, and...

Economic biochemical conversion of cellulose to sugars necessitates minimal addition of water to biomass slurries during conversion, resulting in high-solids systems. The resulting slurries are effectively wet-granular materials. These materials presents difficulties for reactor engineering, as...

Furfural is an important chemical and also a building block for production of drop-in hydrocarbon fuels and can be produced from cellulosic biomass such as woody crops and bagasse by hydrolysis and dehydration with mineral acids. However, furfural yields employing current technologies are limited...

In the biopharmaceutical industry, consistently manufacturing a safe and high quality protein drug substance can be challenging. Recently, a regulatory structure supporting Quality by Design (QbD) for pharmaceuticals and biopharmaceuticals has been described in International Conference on...

Preparation of Mesoporous Silica-supported Palladium Catalyst for Biofuel Upgrade Ling Fei, Joshua Hill, Qianglu Lin, Yun Xu, Shuguang Deng, Hongmei Luo Department of Chemical Engineering, New Mexico State University, Las Cruces, NM 88003 A large number of reactions in organic chemistry (such as...

One of the limitations of screening enzyme combinations using microplate based assays (Gao et al. 2010, Bioresour Technol 101, 8:2770) is that these are typically carried out using milled biomass (1 mm). The crude glycosyl hydrolase mixtures were also analyzed using a high-throughput proteomics...

Saccharification of fermentable sugars is one of the most critical steps in producing bio-ethanol from lignocellulosics through Consolidate Bioprocessing (CBP). However, the extreme pH and ethanol concentration are commonly considered to be the potential inhibitory factors for the application of...