2009

The use of corn as an expression host is an attractive system for the production of plant-made proteins. The use of plants lowers upstream costs making downstream the significant production cost. For some proteins, crossflow ultrafiltration could be a lower cost alternative. The potential for doing...

The title of this session is an expression of the interest on the part of companies and universities to work together to create business opportunity. Universities are becoming key sources of discovery and with recent changes in government funding (amount and process) academia will be playing an...

The pharmacokinetic profiles of monoclonal antibody charge variants are poorly understood because they differ only slightly from the “main” antibody species, are low in abundance, and extremely difficult to isolate in pure pools for intensive in vitro and in vivo studies. Because of this, the...

Recently, Surface-enhanced Raman scattering (SERS) has attracted great attention because of its high sensitivity, label-free detection, and low detection limit. Additionally, it provides a specific fingerprint spectrum of multiplex samples with narrow band width. Because of these advantages, a...

Bioactive papers and paper diagnostics are getting a reality for their low cost, selectivity and application flexibility. Critical is the thermal stability of bioactive papers that need to be shipped and stored. This study quantifies the thermal stability and reactivity of enzymatic bioactive...

Glass-lined reactors are typically used in the pharmaceutical and specialty chemicals industries because of their material compatibility with most reactants and their cleanability. These reactors are typically equipped with a retreat-blade impeller placed close to the bottom of the tank a single...

DNA-biosensors allow rapid, real-time monitoring of hybridization with the target nucleic acids. These biosensors are gaining more attention over traditional diagnostic methods for their fast and responsive operation, and their cost effective design. Specificity of the system relies on...

Smart process manufacturing (SPM) refers to a design and operational paradigm involving the integration of measurement and actuation; environment, safety, and health (ES&H) protection; regulatory control; real-time optimization and monitoring; and planning and scheduling. It is motivated by...

Advanced Process Control (APC) is a key element of the Smart Manufacturing paradigm, that helps drive the operation toward it's optimum point. For many common processes, such as distillation columns, fractionators, fired heaters, boilers or blenders, the APC strategies, calculations and control...

Session highlights and fundamentals of smart manufacturing plants will be presented.