2008

Purifying Therapeutic Monoclonal Antibodies

May
2008
SBE Special Section
Amit Mehta, Amy Len, Benedicte Lebreton, Bradley Wolk, Jace Fogle, Martha Lovato Tse, Nuno Fontes, Robert van Reis, Roshan Shrestha
Eliminating the affinity chromatography step in the mAb purification process trims equipment requirements, shrinks the plant footprint— and reduces costs.

Understand Discrete Nanoscale Transport

June
2008
On The Horizon
Anh-Tuan Dinh, Chinmay Pangarkar, Samir Mitragotri
Unlike mass, energy and momentum transfer, which are described by continuum equations, the movements and interactions of the nanoscale entitites within a cell constitute the transport phenomenon known as discrete nanoscale transport (DNT).

Evaluating Toll Manufacturers

September
2008
Management
Osman Aboul-Nasr
This alternative production approach can offer significant time and capital cost savings. The key is to choose a qualified toller.

Getting to Win-Win

September
2008
Career Catalyst
Eldon R. Larsen, Ryland W. Musick Jr.
Conflict is an almost unavoidable part of life and work, and it can lead to surprisingly constructive opportunities. Here is a discussion of how to manage conflicts— and how to make the most of them when they occur.

The Future of Coal-Based Power Generation

March
2008
Special Section
James R. Katzer
Despite its image as a dirty fuel, coal remains an economic choice for baseload power generation—and it can, in fact, have very low emissions.

Evaluating Cooling Tower Upgrades

May
2008
Heat Transfer
Tom Dendy
When considering improvements to cooling towers, it's important to perform an economic analysis of the options.

Speeding the Design of Bioprocesses

May
2008
SBE Special Section
Andrew D. Tustian, Sunil Chhatre
These experimental and modeling techniques enable the rapid, cost-effective design and scale-up of biopharmaceutical manufacturing in an integrated fashion.

Analyzing Equilibrium when Noncondensables Are Present

April
2008
Environmental Management
Allen Hatfield
With the simplifying assumption that all of the noncondensable gases exit via the vapor stream, material balances and equilibrium calculations can be used to determine the compositions of the emissions streams leaving a control device.

Nanomaterials: What are the Environmental and Health Impacts?

December
2008
Critical Issues
Nastassja Lewinski
As with previous emerging technologies, there have been uncertainties and concerns about the environmental and health risks associated with nanotechnology. This article reviews some of the ongoing efforts to better understand and characterize...

Conference Explores Developing Bioeconomy

March
2008
Special Section
Brad Buecker
Infrastructure, biomass conversion, sources of biomass, and environmental and other impacts are some of the challenges facing the commercialization of biofuels.

Dealing with Climate Change at the Local Level

February
2008
Opinion
Paul A. Jennings
Whatever problems may be caused by climate change, engineers will be expected to solve them.Now is the time to begin addressing the issues at the local and regional scale.

Use Model-Predictive Control to Improve Distillation Operations

January
2008
Instrumentation
Daniel R. Webb, Robert D. Rounding, Robert J. Conroy, Umesh Mathur
This methodology, based on steady-state and dynamic simulation, can be used to develop the necessary models— and avoid disruptive and costly step testing to the extent feasible.
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