AIChE Annual Meeting

Assessing Excipient Variability within QbD Drug Product Development

Oct 30, 2012
Joseph Kushner
Understanding variability in excipient physico-chemical properties is becoming an important aspect of Quality-by-Design (QbD) drug product development. However, present experimental methods are only able to study a few physico-chemical properties on a few excipient lots due to time, cost, and...

Thermal Reduction of Magnetically Stabilized Ferrites Under Reduced Pressure

Oct 30, 2012
Nicholas AuYeung
Oxidation of a metal (or metal oxide) by H 2 O and CO 2 followed by a regenerative high temperature thermal reduction of the resulting metal oxide is a promising method for using concentrated solar energy to produce syngas, a precursor for liquid fuels. For such a process to become viable, the...

The Role of PAT, Condition Monitoring and Adaptive Control in Delivering QbD

Oct 29, 2012
Steve Hammond
“The Role of PAT, Condition Monitoring and Adaptive Control in Delivering QbD” Stephen Hammond, Mark Smith, Pfizer Global Supply, Peapack NJ, USA The use of spectroscopic techniques such as NIR spectroscopy to deliver greater process understanding, either providing difficult to obtain compositional...

Modelling of a Filter Drying Process

Oct 29, 2012
Mark A. Pinto
Filter drying, also referred to as vacuum contact drying, is a process widely used in the pharmaceutical industry to remove water or organic solvents. The advantage of this process over other drying operations is that it can be used to dry solids that are sensitive to oxygen and temperature. The...

Exceptional Event Managemnt Applied to Continuous Pharmaceutical Manufacturing

Oct 29, 2012
Anshu Gupta
One of the important challenges in effective real time process management is the implementation of intelligent systems that can assist human operators in making supervisory control decisions, instead of simply sounding an alarm when process variables go out of range. Operator failures to exercise...

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