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July 2009, Vol. 105, No. 7
In This Issue
CAREER CATALYST
Disarming the Firing Squad
If thoughts of a layoff keep you up at night, stop wringing your hands and start taking action. Follow this 11-step plan to position yourself for success in these uncertain economic times.
Kate Wendleton
SAFETY
Managing Security Risks
Process hazard analysis techniques can be modified to address plant security through a security vulnerability analysis.
Donald W. Abrahamson and Adrian L. Sepeda
FLUIDS AND SOLIDS HANDLING
Reshaping the Structure of Fluidized Beds
Adding structure to a gas-solid fluidized-bed reactor changes the system’s hydrodynamics and can improve performance.
J. Ruud van Ommen, John Nijenhuis, and Marc-Olivier Coppens
BACK TO BASICS
Understanding Sealing Solutions
The right seal can help a plant save money, eliminate leaks, and avoid safety problems. Here’s how to select and install gaskets for effective sealing.
Jim Drago and Matt Tones
SBE SPECIAL SECTION: DISPOSABLE EQUIPMENT
SBE Update
Improving Biopharmaceutical Development
June C. Wispelwey
Exploring New Paradigms for Bioprocessing
Disruptive technologies, such as disposable bioreactors, metabolic flux models, and glycoengineered yeast, could change the face — and pace — of biomanufacturing.
Jonathan Monk
The New Disposable Evolution
Single-use systems have advanced from a limited product line to several new products for a wider range of unit operations. As these technologies evolve, new size, cost, and regulatory needs continue to fuel industry growth.
Joanna Ziemlewski
Disposable vs. Traditional Equipment — A Facility-Wide View
This analysis shows how to quantify the capital and operating differences between single-use and reusable equipment for a model biopharmaceutical process.
Craig Sandstrom