Challenges in Applying PSM to Production Pilot Plants & Laboratories

Global Congress on Process Safety
April 3, 2012 - 12:00am

The CordenPharma Colorado, Inc. (CPC) site in Boulder includes at least eight production facilities. The majority (six) are production laboratories and pilot plants, with synthesizers and vessels of a few liters to a few thousand liters. All of the production process systems are connected to at least one of the site's bulk chemical tank farms, so even processes that are in lab hoods fall under the PSM rule. Because CPC manufactures a wide variety of peptides and small molecule pharmaceuticals for many customers, process and plant configurations are seldom static; some process trains are in use for only a few weeks at a time.

CPC strongly supports PSM as good engineering and operating (and lab) practice, but there are certainly challenges to complying with the intent and purpose of PSM in a dynamic, laboratory-scale operation, where reactors and vessels are glassware, and the interconnecting piping can be short runs of polymer hose. Further, CPC facilities include large, production-scale equipment that are usually considered lab equipment, such as High Pressure Liquid Chromatography columns, where there is little recognized good engineering practice to follow.

The site has solidly implemented discipline to assure that it is following PSM, and is open to sharing what has been learned with other small-scale production operations. These include learnings and practices in design and engineering, Mechanical Integrity, Process Safety Information packages, Change Management, incident reporting and investigation, inter-plant and inter-process emergency response, contaminant isolation and controls, and pressure safety controls, all of which will be briefly presented.

Professional Development Hours
0.5 PDHs
You will be able to download and print a certificate for these PDH credits once the content has been viewed. If you have already viewed this content, please click here to login.
Presenter(s): 

Would you like to access this content?

No problem. You just have to complete the following steps.

You have completed 0 of 2 steps.

  1. Log in

    You must be logged in to view this content. Log in now.

  2. Purchase Technical Presentation

    You must purchase this technical presentation using one of the options below.
    If you already purchased this content recently, please click here to refresh the system's record of ownerships.

Pricing

Credits 0.5 Use credits
List Price $25.00 Buy now
AIChE Members $15.00 Buy now
AIChE Undergraduate Student Members Free Free access
AIChE Graduate Student Members $15.00 Buy now