New Technologies from Engineered Chimeric Proteins
- Type: Archived Webinar
We engineer designer fusion proteins that combine domains and functions from unrelated proteins and enzymes. In bioseparations, we have combined a previously developed pH-sensitive self-cleaving protein with a variety of purification tags to produce simple and economical methods for purifying recombinant proteins. In biosensing, we have developed allosteric proteins that cause Escherichia coli strains to become growth-dependent on endocrine active compounds. Remarkably, this genetically simple bacterial sensor can differentiate agonist from antagonist activities and has been effective in detecting estrogenicity in a wide variety of pollutants, home products and natural herbal remedies.
David Wood received a double major in Chemical Engineering and Molecular Biology from Caltech in 1990. He then worked one year at Kelco in process development for commodity-scale mucopolysaccharides, and two years at Amgen in the Neupogen® manufacturing process. He then returned to graduate school and completed his PhD at Rensselaer Polytechnic Institute in 2001. He then spent seven years on the faculty at Princeton University before joining the Chemical and Biomolecular Engineering Department at the Ohio State University in 2009. His current work includes protein engineering for...Read more
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