Mixture DOE and Design Space
- Type: Conference Presentation
- Conference Type:
AIChE Annual Meeting
- Presentation Date:
November 10, 2010
- Skill Level:
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Present a case study on mixture DOE involving five components used to formulate a pharmaceutical tablet. The goal is to achieve a sustained release by optimizing the concentration of a hydrophilic polymer in relation to the proportions of a drug and three excipients. Four responses (two related to release) are measured and modeled. Then numeric and graphical optimization are used to define a design space.