SBE is offering eight lectures in two parallel series on the theme of systems and synthetic biology. The former focuses on biologics, with the emphasis on applying genomic and global analytical tools to enhance QbD practice. The second series features synthetic pathway engineering, pathway modeling, synthetic circuit to synthetic organisms and communities. Given by seven prominent lecturers, the course is supplemented by comprehensive lecture notes. The course will start at 12:30 pm and adjourn at 5:30 pm. Registrant for either course will receive lecture notes for both and can cross over to attend lecture(s) of the other series.
S8: Genome Technology in Industrial Cell Bioprocessing - Toward QbD in Cell Culture Biologics
4 Lectures: Professionals $349, Students/Grad Students $149
12:30 pm - 5:30 pm - Sunday October 18th, 2011
Coordinating Instructor: Dr. Wei-Shou Hu, University of Minnesota
Other Presenting Instructors: Dr. Sarika Mehra (IIT Bombay), Dr. Ziomara Gerdtzen (Universidad de Chile), Dr. Huong Le (University of Minnesota), Dr. Kathryn Johnson (University of Minnesota)
Overview:
This Genome Technology in Industrial Cell Bioprocessing Toward QbD in Cell Culture Biologics (S8) lecture will discuss global process and product analytical technologies with an emphasis on transcriptome and proteome analysis for industrial cell lines. Both cell and genome engineering will be explored for full exploitation of robust process and product development. Additionally, models for metabolism and glycosylation will be covered from analysis to design. Always relevant to industry, process data mining as well as process intervention will be addressed. A discussion will follow this lecture series to further understanding.
S9: Synthetic Biology for Bioengineering
4 Lectures: Professionals $349, Students/Grad Students $149
12:30 pm - 5:30 pm - Sunday October 18th, 2011
Coordinating Instructor: Dr. Wei-Shou Hu, University of Minnesota
Other Presenting Instructors: Dr. Friedrich Srienc (University of Minnesota), Dr. Yiannis Kaznessis (University of Minnesota), Dr. Claudia Schmidt-Dannert (University of Minnesota), Dr. Kechum Zhang (University of Minnesota), Bhanu Mulukutla (University of Minnesota)
Overview:
The Synthetic Biology for Bioengineering (S9) lecture will explore synthetic pathways, which continue to be modified and streamlined by biological engineers for use in highly specific processes in research and industry. Models for designing pathways in organisms will be discussed and expanded upon. Synthetic genetic circuits will be introduced as an effective tool in population and molecular signaling control. Finally, approaches to the creation of synthetic organisms and communities will be shared. A discussion will be held after the lecture series.
About the instructor:
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Dr. Hu s research area is in bioengineering, with emphasis on bioprocessing, stem cell technology and genomics. A central theme of his research is applying engineering analysis to biochemical and cellular systems and integrating physiological insights into quantitative modeling of biological systems. The systems employed include mammalian cells, stem cells, differentiated tissue cells and microorganisms of Streptomycetes and Enterococci. Current research efforts emphasize exploiting genomics and proteomics in advancing scientific exploration and expanding systems analysis of cellular processes to generate new understanding of gene expression regulation.