Towards Genome Engineering in Chinese Hamster Ovary Cells
Dr. Wei-Shou Hu, University of Minnesota
Tuesday, December 14, 2010 2-3:30PM EDT
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About the Webinar
Worth over $30 billion, therapeutic proteins, produced by recombinant mammalian cells, have been the fastest growing class of medicines in industrialized nations. Their importance in the health industry in the next decade will be ever greater as their reach expands, improving the quality of life of millions. Critical to the quality of the manufactured product and the robustness of the process is the producing cell. Over three quarters of these products are produced by CHO cells. Advances in DNA sequencing technology in the past few years have afforded the possibility of decoding the entire genome of these cells. Armed with the genome sequence information, one can contemplate specifically altering their sequence and even modifying their genome. This presentation will review genome and sequencing basics, highlight genome information processing, exemplify sequence utility and envision the potential impact of the genome on process advancement and innovation.
About the Presenters
Prof. Wei-Shou Hu is a Distinguished McKnight University Professor in the Department of Chemical Engineering and Materials Science at the University of Minnesota (Phone: (612) 625-0546; Fax: (612) 626-7246; E-mail: acre@cems.umn.edu). His research currently focuses on a broad range of cell culture engineering, especially the elucidation of gene-trait relationships through transcriptome and proteome analysis, mining of large scale bioprocess data and mammalian cell metabolism. He holds a BS in Agricultural Chemistry from National Taiwan University, and SM and PhD degrees in Biochemical Engineering from MIT. He is a member of AIChE and currently serves on the advisory board of the Society for Biological Engineering.