Body-On-A-Chip: A Tool for Predictive Pharmacology/Toxicology
SBE Webinar: Body-On-A-Chip: A Tool for Predictive Pharmacology/Toxicology
Tuesday, March 31, 2009 at 2:00-3:00 PM EST
Michael L. Shuler, Department of Biomedical Engineering, Cornell University
SBE Members can watch the archived webinar here for free!
Professor Shuler's answers to questions asked during the webinar are available here.
About this Webinar
In this presentation, Professor Mike Shuler will detail his work to understand the response of the human body to various pharmaceutical and environmental chemicals using a combination of whole body modules and micro models. Professor Shuler’s research focuses on microfabricated devices combined with cell cultures. This combination provides a viable alternative to animal models to predict toxicity and response to pharmaceuticals. To date his models of the GI tract have been used to examine the response to oral exposure of drugs, chemicals, and nanoparticles. These coupled GI tract/body modules have been used to mimic human response to acetaminophen plus ethanol and have shown that nanoparticles can interfere with normal physiological responses such as iron uptake and nutrition. Attend this webinar to learn more about the exciting work being done in the field of predictive pharmacology.
M.L. Shuler Biosketch:
Michael L. Shuler is the James and Marsha McCormick Chair of the Department of Biomedical Engineering as well as the Samuel B. Eckert Professor of Chemical Engineering in the School of Chemical and Biomolecular Engineering at Cornell University, Ithaca, New York. He was also a NYSTAR Distinguished Professor (2001-2006). Shuler received both of his degrees in chemical engineering (BS, University of Notre Dame, 1969 and PhD., University of Minnesota, 1973) and has been a faculty member at Cornell University since January 1974. Shuler’s research is focused on biomolecular engineering and includes development of an “artificial” animal (in vitro) for testing pharmaceuticals and chemicals for toxicity, bioprocess production systems for useful compounds, such aspaclitaxel from plant cell cultures, production of foreign proteins using a wide variety of genetically engineered hosts, and computer models of cells relating physiological function to genomic structure. Shuler has co-authored a popular textbook in bioprocess engineering (selected by AIChE as among 30 authors of groundbreaking chemical engineering texts). Shuler has been elected to the National Academy of Engineering and American Academy of Arts and Sciences. He has received numerous awards for research, teaching, and advising of students.
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