Syrris

stainless steel reactor vessel
A new stainless steel reactor vessel and a high-temperature upgrade kit are available to expand the flexibility and capabilities of this company’s Atlas product line. Using the same jacketed vessel clamp, oil drain unit, and fluid pipe connectors as the existing Atlas Potassium system, the standard glass vessel can be easily exchanged for the stainless steel version in under a minute. Available in a range of sizes from 100 mL to 5 L, the system has an integrated bottom outlet valve that compensates for any thermal expansion, while the torispherical profile and consistent length-to-diameter ratio mimic the dimensions of large-scale plant reactors. The stainless steel vessel is ideal for use with sodium hydroxide and other highly basic substances that would etch glass. A new temperature-upgrade kit also enables the Atlas glass or stainless steel jacketed reactors to increase the existing temperature range of –80°C to 200°C to 250°C, making it suitable for higher-temperature applications.

Asia syringe pump
Made from chemically resistant polytetrafluoroethylene (PTFE) and glass, the Asia syringe pump is rated to 20 bar (300 psi). This compact (23-cm wide) module offers two independent continuous-flow channels, each with an integrated pressure sensor and a flowrate range of 1.0 µL to 10 mL/min. Replacement of component valves, syringes or pressure sensors is quick and easy, requiring no tools. Flowrate and volume can be controlled using the intuitive front panel, or by means of the Asia PC software. The PTFE pressure sensor ensures safe operation by automatically stopping the pump when overpressure conditions are detected.

Medstere software
Medstere software shortens lead-seeking optimization cycles by generating hundreds of non-obvious alternatives to a known form of a drug. It assesses the similarity of structurally diverse biosteres using the 3-D surface and electrostatic properties of molecules. The user first inputs the known molecule and selects the area to be changed. The software converts the 3-D (or 2-D) molecule into field points, then replaces the selected section with thousands of alternative fragments, while creating field points for all the new molecules. Finally, the software compares the input molecule with all of the alternatives, taking its similarity of location and size into account to assign a score to each. Its smart chemistry rules ensure practical results that can be readily synthesized. This process allows novel and unexpected structural scaffolds to be generated, which is important because they exhibit similar biological activities and properties while avoiding conflicts with existing intellectual property.

Atlas Reporting
Atlas Reporting enables easy graphical analysis of sophisticated log files generated by the Atlas Base Unit, Atlas Software or Atlas Syringe Pump. These graphs can be created in seconds using the included wizard, which incorporates an easy-to-use, drag-and-drop interface. Files from Atlas modules and other software can be uploaded via a USB stick to enable graphs to be created, customized and printed. Multiple files can be imported simultaneously, allowing various parameters from different experiments to be plotted on the same graph for comprehensive batch-to-batch analysis. The software also displays comments added by the user during the experiment; a line on the graph indicates when the comment was added, highlighting correlations between any observations and the data. Graphs of reaction power, reaction enthalpy, overall process enthalpy, and sensible heat of addition are all automatically displayed.

Atlas dry baths
Designed to operate at temperatures up to 280°C, Atlas dry baths offer a safer and more efficient heating option for round-bottom flasks or vials without the risk and mess of oil baths. Compatible with leading brands of hotplates, the stacking dry bath is both compact and flexible. Its series of concentric cups accommodates flasks of varying volume, from 50 mL to 1 L. The triple dry bath is available for three flasks with capacities ranging from 50 mL to 250 mL. A protective safety shield enables the module to be quickly picked up and moved in the case of an emergency. The shield facilitates the rapid cooling of a reaction for work-up and purification via a natural convection airflow. The unique cup design prevents the cracking of glassware and a temperature probe hole for every cup facilitates intimate contact with reactors. The use of deep cups optimizes heat-transfer surface area and reduces heat-up time. The dry bath is part of the Atlas automated synthesis system, a low-cost, intelligent modular system that is simple to use and quick to set up. Using a fully modular approach, the Atlas base unit can be configured into a wide range of systems to control vials, round-bottom flasks and jacketed vessels. Atlas systems can carry out numerous functions, including heating, stirring, cooling, pH measurement and automated reagent addition.