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October 2007, Vol. 103, No. 10

In This Issue

SOCIETY FOR BIOLOGICAL ENGINEERING SPECIAL SECTION: FROM CHINESE HAMSTERS TO THERAPEUTIC PROTEINS

SBE Update: Taking it to the Next Level

Find out what's new at SBE. The society just marked its third anniversary and is continuing to experience rapid growth from all over the world.

June Wispelwey

Industry and SBE News

•Dr. George Georgiou to Receive SBE's James E. Bailey Award  •Averting an Epidemic — Novel Device Detects Avian Flu Virus in Less than Half an Hour •Cell-Free Protein Sythesis Comes of Age  •Genetically Engineering Microorganisms into Pharmaceutical Factories


Singapore: An Emerging Leader in Biomedical Sciences

With a heavy investment in biomedical research — particularly the $330 million to build Biopolis in 2003 — Singapore is seeing the fruits of its labor blossom.

Niki S. C. Wong and Miranda G. S. Yap

Recombinant Protein Therapeutics from CHO Cells -- 20 Years and Counting

The CHO cell is at its height of technological prominence thanks to its adaptability to various culture conditions and plasticity in the context of genetic alterations. With further research, the application of Cell Culture Strategies based on scientific reasoning, rather than heuristics, is in the not-so distant future. 

Karthik P. Jayapal, Katie F Wlaschin, Wei-Shou Hu and Miranda G. S. Yap

Deciphering the Mechanisms of Therapeutic Protein Production

Demand for therapeutic recombinant proteins will eventually exceed current production capabilities. This is a major driver in further understanding Chinese Hamster Ovary (CHO) cell biology, which is the cell line of choice for producing these proteins. Further R&D into CHO is expected to improve production capacity.

Daniel W. Allison, Trissa Borgschulte, Christoph L. Bausch, Matthew V. Caple and Kevin J. Kayser
ENVIRONMENTAL MANAGEMENT

Understand the Emerging Issue of Vapor Intrusion

The migration of vapors from contaminated groundwater and soil into aboveground buildings can adversely affect indoor air quality by creating an exposure pathway that may not have been addressed previously.

Matthew Traister
HEAT TRANSFER

Avoid Problems in Process Water Systems

Prevent corrosion, emulsification and fouling by implementing these operational and chemical measures.

Roger D. Metzler and Marilyn W. Blaschke
CHEM SHOW SPONSORED LINKS

Delta Cooling Towers: Corrosion Proof Engineered Plastic Cooling Towers

Manufacturer of seamless engineered plastic cooling towers, ranging from 10 to 2000 ton capacities. The towers incorporate a high efficiency counter-flow design, which is molded into a unitary leak-proof structure.  All models are factory assembled, simple to install and nearly maintenance free.  15-year warranty*.  Packaged Pump/Control Skids and Storage Tanks also available. 1-800-BUY-DELTA.

www.deltacooling.com

High Purity Hose for Chemical, Pharmaceutical, & Clean Applications

AdvantaPure, the high purity products division of NewAge Industries, will have a variety of fluoropolymer, silicone, and EPDM hoses on display at the Chem Show for applications involving chemical transfer, air and gas lines, processing, water and fluid drains, and more. Click for info or explore samples at Chem Show booth 1630. 

AdvantaPure(R), E-mail: cep@advantapure.com, www.advantapure.com

Precision Dispensers & Metering Pumps

 Fluid Metering, Inc. offers a full line of Dispensers and Metering Pumps for Laboratory, Industrial and OEM applications. FMI’s unique piston-type positive displacement units feature no valves, low-dead volume, 1% accuracy and a ceramic/fluorocarbon fluid path.. Flows from 2.5 µl/dispense to flows of 4,600 ml/min with pressures to 100 psig. Fluid Metering is certified as compliant with ISO 9001 quality standards.

Fluid Metering Inc., 5 Aerial Way, Suite 500, Syosset, NY 11791, USA. Call toll free (800) 223-3388 or 1-(516) 922-6050, FAX 1-(516)624-826, Email: pumps@fmipump.com, Website: www.fmipump.com

Larox eccentric design hose pumps rolls over conventional hose pumps

Larox Pumps radical cost advantage over other hose and centrifugal pumps. Larox pumps heavy slurries, viscous, or aggressive media. Utilizing a unique rolling design eliminating friction, hose wear, and lowers energy. Hose compression only once per revolution. 1 yr. operating savings by using Larox often saves enough for a new pump

www.larox.us

INOX-TECH: Specializing in Engineering, Fabrication and System Integration

By carrying out custom engineering, fabrication, and installation of stainless steel equipment and/or turnkey process systems with its in-house staff, INOX-TECH offers customers in the food, biotech, chemical, alternative fuel and other industries a "ONE-STOP Solution" to meeting their liquid process requirements.    

E-mail: info@inox-tech.com www.inox-tech.com

Engineer’s Aide CHEMPRO 8 for Fluid Flow and Process Simulation

The new Engineer’s Aide CHEMPRO 8TM  excels where others fail including 3-phase flash calculations for challenging aqueous-hydrocarbon systems.  CHEMPRO 8 combines fluid flow and process simulation and handles both normal and upset conditions.  Based on industry standard API thermodynamics and methods,  CHEMPRO 8 simulates liquid, gas, and multi-phase piping systems and compressor performance.  

Contact EPCON International for a software demonstration today – 800-367-3585, www.epcon.com

CHEMCAD Suite of Simulation Software, Version 6.0

Chemstations proudly announces the latest release of the CHEMCAD suite of simulation software: version 6.0.  The latest version builds on our commitment to innovation, integration, and open architecture with significant improvements in both the graphical user interface and the core engineering functionality of the program.  Almost three staff-years of effort, dozens of hours of customer interviews, and decades of internal experience were focused to deliver a state of the art process simulation package that seamlessly integrates into the wider chemical engineering computing environment. Current and new users will appreciate the usability, flowsheet convergence, and extensibility enhancements. We invite all CHEMSHOW attendees to visit booth #1629 for a demonstration and to find out why over 1000 organizations worldwide have chosen CHEMCAD!


High Flow, Corrosion Resistant Molded Pumps

A new line of molded pumps by SERFILCO® excels with high flows (400+ gpm or 170 TDH) using low horsepower for efficient operation.  SERFILCO offers customers in the chemical, general industrial, water treatment and pollution control industries a one-stop solution for a full range of corrosion resistant pumps and filtration equipment.

SERFILCO® ; E-mail: sales@serfilco.com ; www.serfilco.com